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编 号：F020227
分子式：C12H15Cl2NO2
分子量：276.16
分子式：C12H15Cl2NO2
分子量：276.16
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CAS No: 10477-72-2
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生物活性：
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an?alkylating?agent with antitumor activity.
体内研究：
Phenylacetic acid mustard (intraperitoneal?injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency thanCHL, it exhibits an ED15 value of 8.0 mg/kg.Phenylacetic acid mustard (intraperitoneal?injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg.Animal Model:Inbred male C3H/He mice
Dosage:0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration:Intraperitoneal?injection; 15 days
Result:Exhibited anti-tumor activities in vivo.
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an?alkylating?agent with antitumor activity.
体内研究：
Phenylacetic acid mustard (intraperitoneal?injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency thanCHL, it exhibits an ED15 value of 8.0 mg/kg.Phenylacetic acid mustard (intraperitoneal?injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg.Animal Model:Inbred male C3H/He mice
Dosage:0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration:Intraperitoneal?injection; 15 days
Result:Exhibited anti-tumor activities in vivo.
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