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编 号：F179661
分子式：C31H46N8O6S
分子量：658.81
分子式：C31H46N8O6S
分子量：658.81
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CAS No: 152165-14-5
产品详情
生物活性：
Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.
体内研究：
Phe-Met-Arg-Phe, amide (FMRFamide) acetate stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 pM) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 pM) of FMRFamide is already developed after 5 min and lasted up to 30 min.
体外研究：
In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acetate acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide acetate activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe, amide (1 μM) acetate significantly inhibits glucose stimulated (300 mg/dL) insulin release (pPhe-Met-Arg-Phe, amide acetate 相关抗体:
Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.
体内研究：
Phe-Met-Arg-Phe, amide (FMRFamide) acetate stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 pM) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 pM) of FMRFamide is already developed after 5 min and lasted up to 30 min.
体外研究：
In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acetate acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide acetate activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe, amide (1 μM) acetate significantly inhibits glucose stimulated (300 mg/dL) insulin release (pPhe-Met-Arg-Phe, amide acetate 相关抗体:
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