产品
编 号：F179024
分子式：C16H15ClN6O3
分子量：374.78
分子式：C16H15ClN6O3
分子量：374.78
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CAS No: 151776-26-0
产品详情
生物活性：
(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABAA receptor and inhibits nACh and NMDA receptors.
体外研究：
Micromolar concentrations of (S)-Norzopiclone (SEP-174559) potentiates GABAA receptor currents evoked by subsaturating concentrations of GABA. (S)-Norzopiclone9 is not selective between alpha1-, alpha2-, or alpha3-bearing GABAA receptors. Within the nicotinic receptor superfamily, (S)-Norzopiclone does not affect serotonin type-3 receptor function but is found to inhibit nACh receptors.In the glutamate receptor superfamily, (S)-Norzopiclone inhibits N-methyl-D-aspartate (NMDA) receptor currents but does not affect non-NMDA receptors.
(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABAA receptor and inhibits nACh and NMDA receptors.
体外研究：
Micromolar concentrations of (S)-Norzopiclone (SEP-174559) potentiates GABAA receptor currents evoked by subsaturating concentrations of GABA. (S)-Norzopiclone9 is not selective between alpha1-, alpha2-, or alpha3-bearing GABAA receptors. Within the nicotinic receptor superfamily, (S)-Norzopiclone does not affect serotonin type-3 receptor function but is found to inhibit nACh receptors.In the glutamate receptor superfamily, (S)-Norzopiclone inhibits N-methyl-D-aspartate (NMDA) receptor currents but does not affect non-NMDA receptors.
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