产品
编 号：F178398
分子式：C24H27F2N5O4
分子量：487.5
分子式：C24H27F2N5O4
分子量：487.5
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
1032
In-stock
1mg
400
In-stock
5mg
960
In-stock
10mg
1520
In-stock
25mg
2640
In-stock
50mg
询价
In-stock
100mg
询价
In-stock
结构图
CAS No: 1513857-77-6
产品详情
生物活性：
Pemigatinib (INCB054828) is an orally active, selective FGFR inhibitor with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.
体外研究：
表达 FGFR2-CLIP1 融合的细胞对 Pemigatinib 敏感 (INCB054828；IC50 值为 10.16 nM)，而添加 N549H 突变的细胞对 Pemigatinib 具有耐药性 (IC50 值为 1527.57 nM)。
Pemigatinib (INCB054828) is an orally active, selective FGFR inhibitor with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.
体外研究：
表达 FGFR2-CLIP1 融合的细胞对 Pemigatinib 敏感 (INCB054828；IC50 值为 10.16 nM)，而添加 N549H 突变的细胞对 Pemigatinib 具有耐药性 (IC50 值为 1527.57 nM)。
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