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编 号：F178109
分子式：C25H33Cl2N5O7
分子量：586.46
分子式：C25H33Cl2N5O7
分子量：586.46
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CAS No: 151201-76-2
产品详情
生物活性：
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression.
体内研究：
Astin B (10 mg/kg，口服，每天一次，连续 7 天) 诱导小鼠肝损伤。Animal Model:Male ICR mice (6–8 weeks of age, 10 per group)
Dosage:10 mg/kg
Administration:Orally administered, once daily for 7 consecutive days
Result:Induced liver injury in mice. Compared to the control group, the serum levels of ALT and AST in mice treated with astin B were elevated about 11.9 and 2.26 times, respectively.
体外研究：
Astin B (0-60 μM, 12-48 h) 抑制 L-02 细胞的增殖。Astin B (0-60 μM, 24 h) 诱导氧化应激和线粒体功能障碍，调节 Bcl-2/Bax 表达并增加 caspase-3 和 -9 活性。Astin B (0-60 μM, 24 h) 在 L-02 细胞中诱导自噬以防止细胞凋亡。Astin B 在肝细胞中引起氧化应激相关炎症，活性氧 (ROS) 水平升高、细胞内谷胱甘肽 (GSH) 含量降低以及 c-Jun 氨基末端激酶 (JNK) 磷酸化增强得到证实。
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression.
体内研究：
Astin B (10 mg/kg，口服，每天一次，连续 7 天) 诱导小鼠肝损伤。Animal Model:Male ICR mice (6–8 weeks of age, 10 per group)
Dosage:10 mg/kg
Administration:Orally administered, once daily for 7 consecutive days
Result:Induced liver injury in mice. Compared to the control group, the serum levels of ALT and AST in mice treated with astin B were elevated about 11.9 and 2.26 times, respectively.
体外研究：
Astin B (0-60 μM, 12-48 h) 抑制 L-02 细胞的增殖。Astin B (0-60 μM, 24 h) 诱导氧化应激和线粒体功能障碍，调节 Bcl-2/Bax 表达并增加 caspase-3 和 -9 活性。Astin B (0-60 μM, 24 h) 在 L-02 细胞中诱导自噬以防止细胞凋亡。Astin B 在肝细胞中引起氧化应激相关炎症，活性氧 (ROS) 水平升高、细胞内谷胱甘肽 (GSH) 含量降低以及 c-Jun 氨基末端激酶 (JNK) 磷酸化增强得到证实。
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