产品
编 号：F177590
分子式：C19H30ClNO
分子量：323.9
分子式：C19H30ClNO
分子量：323.9
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
结构图
CAS No: 1508-76-5
产品详情
生物活性：
Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy.
体内研究：
Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) hydrochloride in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether.Animal Model:Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs
Dosage:0.3-6.0 mg/kg
Administration:Subcutaneous injection; once
Result:Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.
Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy.
体内研究：
Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) hydrochloride in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether.Animal Model:Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs
Dosage:0.3-6.0 mg/kg
Administration:Subcutaneous injection; once
Result:Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.
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