产品
编 号：F176811
分子式：C8H18ClN3O2
分子量：223.7
分子式：C8H18ClN3O2
分子量：223.7
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CAS No: 150403-89-7
产品详情
生物活性：
L-NIL hydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for mouse inducible NOS.
体内研究：
L-NIL (10 and 30?mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.Animal Model:Adult male Balb/c (20-25 g).
Dosage:10 and 30?mg/kg.
Administration:Intraperitoneally at the end of CLP and at 6?h after sepsis induction.
Result:Led to a negligible increase in plasma NGAL compared to sham mice.Led to a significant decrease in both TLR4 and IL1β?protein contents and clusterin transcript.Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
体外研究：
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS and the rat brain constitutive NOS (rcNOS) and is considerably more potent for mouse inducible NOS. The IC50 values for L-NIL with mouse inducible NOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for mouse inducible NOS. In addition, L-NIL has approximately 6-fold greater potency for mouse inducible NOS than either L-NMA or L-NNA.
L-NIL hydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for mouse inducible NOS.
体内研究：
L-NIL (10 and 30?mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.Animal Model:Adult male Balb/c (20-25 g).
Dosage:10 and 30?mg/kg.
Administration:Intraperitoneally at the end of CLP and at 6?h after sepsis induction.
Result:Led to a negligible increase in plasma NGAL compared to sham mice.Led to a significant decrease in both TLR4 and IL1β?protein contents and clusterin transcript.Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
体外研究：
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS and the rat brain constitutive NOS (rcNOS) and is considerably more potent for mouse inducible NOS. The IC50 values for L-NIL with mouse inducible NOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for mouse inducible NOS. In addition, L-NIL has approximately 6-fold greater potency for mouse inducible NOS than either L-NMA or L-NNA.
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