产品
编 号：F176789
分子式：C10H13N2Na3O8
分子量：358.19
分子式：C10H13N2Na3O8
分子量：358.19
产品类型
规格
价格
是否有货
500mg
询价
询价
1g
询价
询价
结构图
CAS No: 150-38-9
产品详情
生物活性：
Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research.
体内研究：
Ethylenediaminetetraacetic acid (60 mg/kg; 腹腔注射; 每周三次连续三周 ) 在 CCl4 诱导的肝纤维化大鼠中可以降低肝的纤维化、脂质过氧化和肝脏炎症，具有抗氧化和抗炎活性。Animal Model:Male Wistar rat model of cirrhosis induced by CCl4
Dosage:60 mg/kg, 120 mg/kg, 240 mg/kg
Administration:Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
Result:Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.Reduced fibrosis of the liver in surviving rats (20%).
Animal Model:Male Wistar rat model of cirrhosis induced by CCl
Dosage: 60 mg/kg
Administration:Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
Result:Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
体外研究：
Ethylenediaminetetraacetic acid 对铜绿假单胞菌 (P. aeruginosa) 和粪单胞菌 (a. faecalis) 的细胞壁具有较强的杀菌作用。Ethylenediaminetetraacetic acid (0.005-0.01 M) 在污染粉质粘壤土土柱中具有较好的重金属萃取作用， 能以浓度依赖的方式萃取出 Pb、 Cd 和 Zn，萃取效率顺序为 Pb > Cd > Zn。 Ethylenediaminetetraacetic acid (1.2 mM) 在 HEK293T 细胞中通过激活 t 细胞死亡相关基因 8 (TDAG8) 来增强 CRE 驱动启动子的活性，从而增强了细胞中 cAMP 的产生。
Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research.
体内研究：
Ethylenediaminetetraacetic acid (60 mg/kg; 腹腔注射; 每周三次连续三周 ) 在 CCl4 诱导的肝纤维化大鼠中可以降低肝的纤维化、脂质过氧化和肝脏炎症，具有抗氧化和抗炎活性。Animal Model:Male Wistar rat model of cirrhosis induced by CCl4
Dosage:60 mg/kg, 120 mg/kg, 240 mg/kg
Administration:Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
Result:Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.Reduced fibrosis of the liver in surviving rats (20%).
Animal Model:Male Wistar rat model of cirrhosis induced by CCl
Dosage: 60 mg/kg
Administration:Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
Result:Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
体外研究：
Ethylenediaminetetraacetic acid 对铜绿假单胞菌 (P. aeruginosa) 和粪单胞菌 (a. faecalis) 的细胞壁具有较强的杀菌作用。Ethylenediaminetetraacetic acid (0.005-0.01 M) 在污染粉质粘壤土土柱中具有较好的重金属萃取作用， 能以浓度依赖的方式萃取出 Pb、 Cd 和 Zn，萃取效率顺序为 Pb > Cd > Zn。 Ethylenediaminetetraacetic acid (1.2 mM) 在 HEK293T 细胞中通过激活 t 细胞死亡相关基因 8 (TDAG8) 来增强 CRE 驱动启动子的活性，从而增强了细胞中 cAMP 的产生。
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