产品
编 号：F176695
分子式：C21H23N3O8
分子量：445.42
分子式：C21H23N3O8
分子量：445.42
产品类型
规格
价格
是否有货
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 150323-78-7
产品详情
生物活性：
Quipazine dimaleate is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research.
体内研究：
Quipazine dimaleate (2.5，5 和 7.5 mg/kg，每个剂量各一次；腹腔注射) 影响雄性和雌性大鼠对不同宏量营养素饮食的膳食自我选择。Animal Model:Male and female Wistar rats feed with different sources of the three macronutrients (Group 1: casein, corn starch, safflower oil. Group 2: egg protein, corn starch/sucrose, lard. Group S: casein hydrolysate, maltose dextrin, butter.)
Dosage:2.5, 5 and 7.5 mg/kg
Administration:Intraperitoneal injection; 2.5, 5 and 7.5 mg/kg, one dose for once
Result:Increased water intake and food intake of male rats from Group S, and reduced food intake of female rats from Group 1 and Group 2s at 2h post-injection. Reduced food intake in female rats from Group 2, reduced protein intake in female rats from Group 1.
体外研究：
Quipazine dimaleate 对 5-HT1 和 5-HT2 具有结合效能，Ki 值均为 230 nM。Quipazine dimaleate 取代大鼠内皮层中 5-HT3R 的 [3H]GR65630，Ki 值为 1.4 nM。Quipazine dimaleate 对大鼠迷走神经具有拮抗作用，对 5-HT2，5-HT1 以及抑制 5-HT 释放的 pIC50 值分别为 6.1，6.49 和 6.17。
Quipazine dimaleate is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research.
体内研究：
Quipazine dimaleate (2.5，5 和 7.5 mg/kg，每个剂量各一次；腹腔注射) 影响雄性和雌性大鼠对不同宏量营养素饮食的膳食自我选择。Animal Model:Male and female Wistar rats feed with different sources of the three macronutrients (Group 1: casein, corn starch, safflower oil. Group 2: egg protein, corn starch/sucrose, lard. Group S: casein hydrolysate, maltose dextrin, butter.)
Dosage:2.5, 5 and 7.5 mg/kg
Administration:Intraperitoneal injection; 2.5, 5 and 7.5 mg/kg, one dose for once
Result:Increased water intake and food intake of male rats from Group S, and reduced food intake of female rats from Group 1 and Group 2s at 2h post-injection. Reduced food intake in female rats from Group 2, reduced protein intake in female rats from Group 1.
体外研究：
Quipazine dimaleate 对 5-HT1 和 5-HT2 具有结合效能，Ki 值均为 230 nM。Quipazine dimaleate 取代大鼠内皮层中 5-HT3R 的 [3H]GR65630，Ki 值为 1.4 nM。Quipazine dimaleate 对大鼠迷走神经具有拮抗作用，对 5-HT2，5-HT1 以及抑制 5-HT 释放的 pIC50 值分别为 6.1，6.49 和 6.17。
产品资料
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