产品
编 号:F176354
分子式:C10H11NO4
分子量:209.2
产品类型
结构图
CAS No: 150145-89-4
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产品详情
生物活性:
(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.
体内研究:
Animal Model:Male Lister-Hooded rats in the learning of the Morris water maze
Dosage:20 μg
Administration:Intraventricular injection; 20 μg; 4 days
Result:Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
体外研究:
(S)- MCPG (100 μM) 对 WT 切片培养物中的基底脊柱形成或消除机制没有可检测的影响。(S)- MCPG 可防止 TBS 引发的脊柱更新增加,并干扰海马切片培养物中依赖于活动的脊柱稳定机制。