产品
编 号：F175831
分子式：C29H37F5N4O6
分子量：632.62
分子式：C29H37F5N4O6
分子量：632.62
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CAS No: 149859-17-6
产品详情
生物活性：
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis.
体内研究：
MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis.Animal Model:Rats
Dosage:200 mg/kg
Administration:Oral, 200 mg/kg/day
Result:Inhibited the severity of collagen-induced arthritis.Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.
体外研究：
MDL 101,146 inhibits human neutrophil elastase with a Ki value of 25 nM.MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a Ki value of 18 nM.
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis.
体内研究：
MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis.Animal Model:Rats
Dosage:200 mg/kg
Administration:Oral, 200 mg/kg/day
Result:Inhibited the severity of collagen-induced arthritis.Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.
体外研究：
MDL 101,146 inhibits human neutrophil elastase with a Ki value of 25 nM.MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a Ki value of 18 nM.
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