产品
编 号：F019773
分子式：C10H17N3S
分子量：211.33
分子式：C10H17N3S
分子量：211.33
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
询价
询价
结构图
CAS No: 104632-26-0
产品详情
生物活性：
Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
体内研究：
Pramipexole (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals.Pramipexole improves neurological recovery.Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke.Animal Model:Male Wistar rats weighing 250-300 g (16-18 weeks old)
Dosage:0.25 mg/kg, 1 mg/kg
Administration:Intraperitoneal injection
Result:Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
体外研究：
Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM.Pramipexole (0.01-10?μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size.Pramipexole attenuates levodopa-induced toxicity in mesencephalic cultures.
Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
体内研究：
Pramipexole (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals.Pramipexole improves neurological recovery.Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke.Animal Model:Male Wistar rats weighing 250-300 g (16-18 weeks old)
Dosage:0.25 mg/kg, 1 mg/kg
Administration:Intraperitoneal injection
Result:Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
体外研究：
Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM.Pramipexole (0.01-10?μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size.Pramipexole attenuates levodopa-induced toxicity in mesencephalic cultures.
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