产品
编 号：F175073
分子式：C6H4Na2O8S2
分子量：314.2
分子式：C6H4Na2O8S2
分子量：314.2
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
10g
400
In-stock
25g
800
In-stock
结构图
CAS No: 149-45-1
产品详情
生物活性：
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals.
体内研究：
Tiron (200 mg/kg，灌胃) 改善小鼠气道重塑模型中的氧化应激和炎症。Tiron (300 mg/kg，i.p.，每日一次，持续两周) 减轻了 STZ 诱导的糖尿病小鼠左心室心肌细胞的凋亡。Animal Model:BALB/c mice challenged with Ovalbumin (OVA) aerosol for 8 weeks
Dosage:200 mg/kg
Administration:Oral gavage.
Result:Inhibited levels of NOx, IL-13 and TGF-β1, and immunoreactivity of NF-κB.
Animal Model:STZ-induced diabetic mice
Dosage:300 mg/kg
Administration:i.p., daily for two weeks.
Result:Reduced the levels of total oxidized proteins and advanced glycation end products (AGEs)-related proteins.Inhibited cardiac myocyte apoptosis.Decreased PKCδ localization on plasma membrane.
体外研究：
Tiron (10 mM) 保护中国仓鼠 V79 细胞免受 H2O2 诱导的细胞毒性。Tiron (0-20 mM) 保护超螺旋 DNA 免受金属介导的超氧化物依赖性链断裂。Tiron (50 nM-200 nM, 48 h) 抑制 HG 诱导的新生大鼠心肌细胞凋亡。Tiron (50 nM-200 nM, 48 h) 降低新生大鼠心肌细胞内的骨桥蛋白。Tiron (0.2 mM，2 小时) 抑制 UVB 诱导的 HDF 中 MMP-1 和 MMP-3 的上调。Tiron (0.7 mM，48 小时) 增加 S 期和 G2/M 期 PT4 细胞的百分比。
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals.
体内研究：
Tiron (200 mg/kg，灌胃) 改善小鼠气道重塑模型中的氧化应激和炎症。Tiron (300 mg/kg，i.p.，每日一次，持续两周) 减轻了 STZ 诱导的糖尿病小鼠左心室心肌细胞的凋亡。Animal Model:BALB/c mice challenged with Ovalbumin (OVA) aerosol for 8 weeks
Dosage:200 mg/kg
Administration:Oral gavage.
Result:Inhibited levels of NOx, IL-13 and TGF-β1, and immunoreactivity of NF-κB.
Animal Model:STZ-induced diabetic mice
Dosage:300 mg/kg
Administration:i.p., daily for two weeks.
Result:Reduced the levels of total oxidized proteins and advanced glycation end products (AGEs)-related proteins.Inhibited cardiac myocyte apoptosis.Decreased PKCδ localization on plasma membrane.
体外研究：
Tiron (10 mM) 保护中国仓鼠 V79 细胞免受 H2O2 诱导的细胞毒性。Tiron (0-20 mM) 保护超螺旋 DNA 免受金属介导的超氧化物依赖性链断裂。Tiron (50 nM-200 nM, 48 h) 抑制 HG 诱导的新生大鼠心肌细胞凋亡。Tiron (50 nM-200 nM, 48 h) 降低新生大鼠心肌细胞内的骨桥蛋白。Tiron (0.2 mM，2 小时) 抑制 UVB 诱导的 HDF 中 MMP-1 和 MMP-3 的上调。Tiron (0.7 mM，48 小时) 增加 S 期和 G2/M 期 PT4 细胞的百分比。
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