产品
编 号：F019772
分子式：C10H19Cl2N3S
分子量：284.25
分子式：C10H19Cl2N3S
分子量：284.25
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 104632-25-9
产品详情
生物活性：
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
体内研究：
Pramipexole dihydrochloride (0.25-1 mg/kg；ip) 显著减少动物的梗死体积。Pramipexole dihydrochloride 改善神经功能恢复。 Pramipexole dihydrochloride 通过线粒体途径预防缺血性中风中的缺血性细胞死亡。Animal Model:Male Wistar rats weighing 250-300 g (16-18 weeks old)
Dosage:0.25 mg/kg, 1 mg/kg
Administration:Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusion
Result:Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
体外研究：
Pramipexole dihydrochloride 对 D1 型受体具有低结合亲和力，IC50 >50,000 nM。 Pramipexole dihydrochloride 二盐酸盐 (0.01-10 μM；72 小时) 产生剂量依赖性增加树突状树枝状结构和体细胞大小的影响。盐酸 Pramipexole dihydrochloride 减弱中脑培养物中左旋多巴诱导的毒性，表明 Pramipexole dihydrochloride 可能对组织培养物中的多巴胺神经元具有细胞保护作用。
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
体内研究：
Pramipexole dihydrochloride (0.25-1 mg/kg；ip) 显著减少动物的梗死体积。Pramipexole dihydrochloride 改善神经功能恢复。 Pramipexole dihydrochloride 通过线粒体途径预防缺血性中风中的缺血性细胞死亡。Animal Model:Male Wistar rats weighing 250-300 g (16-18 weeks old)
Dosage:0.25 mg/kg, 1 mg/kg
Administration:Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusion
Result:Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
体外研究：
Pramipexole dihydrochloride 对 D1 型受体具有低结合亲和力，IC50 >50,000 nM。 Pramipexole dihydrochloride 二盐酸盐 (0.01-10 μM；72 小时) 产生剂量依赖性增加树突状树枝状结构和体细胞大小的影响。盐酸 Pramipexole dihydrochloride 减弱中脑培养物中左旋多巴诱导的毒性，表明 Pramipexole dihydrochloride 可能对组织培养物中的多巴胺神经元具有细胞保护作用。
产品资料
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