产品
编 号：F174798
分子式：C7H6O4
分子量：154.12
分子式：C7H6O4
分子量：154.12
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 149-29-1
产品详情
生物活性：
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.
体内研究：
Patulin (1-3.75 mg/kg, 腹腔注射, 一次) 在 CF-1 小鼠中以剂量依赖性方式诱导大脑、肝脏和肾脏 DNA 损伤。Animal Model:Male CF-1 mice
Dosage:1-3.75 mg/kg
Administration:i.p., once time
Result:Increased the damage index and TBARS production in the brain, liver and kidneys of mice in a dose-dependently manner (2.5-3.75 mg/kg).Reduced the concentration of the reduced form of intracellular glutathione in the brain, liver and kidneys of mice at a dose of 2.5-3.75 mg/kg.Decreased the levels of GSH.Increased lipid peroxidation.
体外研究：
Patulin (2 μM, 6-24 h) 在 HepG2 细胞中以自噬依赖性方式诱导 LMP 并减少组织蛋白酶 B 释放。Patulin (2 μM, 6-24 h) 可提高 HepG2 细胞中细胞色素 c 蛋白水平并以自噬依赖性方式诱导细胞凋亡。Patulin (2 μM, 6-24 h) 会损害 HepG2 细胞的线粒体自噬。
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.
体内研究：
Patulin (1-3.75 mg/kg, 腹腔注射, 一次) 在 CF-1 小鼠中以剂量依赖性方式诱导大脑、肝脏和肾脏 DNA 损伤。Animal Model:Male CF-1 mice
Dosage:1-3.75 mg/kg
Administration:i.p., once time
Result:Increased the damage index and TBARS production in the brain, liver and kidneys of mice in a dose-dependently manner (2.5-3.75 mg/kg).Reduced the concentration of the reduced form of intracellular glutathione in the brain, liver and kidneys of mice at a dose of 2.5-3.75 mg/kg.Decreased the levels of GSH.Increased lipid peroxidation.
体外研究：
Patulin (2 μM, 6-24 h) 在 HepG2 细胞中以自噬依赖性方式诱导 LMP 并减少组织蛋白酶 B 释放。Patulin (2 μM, 6-24 h) 可提高 HepG2 细胞中细胞色素 c 蛋白水平并以自噬依赖性方式诱导细胞凋亡。Patulin (2 μM, 6-24 h) 会损害 HepG2 细胞的线粒体自噬。
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