产品
编 号：F174389
分子式：C24H35Cl2N3O2
分子量：468.46
分子式：C24H35Cl2N3O2
分子量：468.46
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 149055-79-8
产品详情
生物活性：
WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties.
体内研究：
WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats.WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats.
体外研究：
WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA2 of 7.2.WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons.
WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties.
体内研究：
WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats.WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats.
体外研究：
WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA2 of 7.2.WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons.
产品资料
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