产品
编 号：F019643
分子式：C10H18O
分子量：154.25
分子式：C10H18O
分子量：154.25
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
结构图
CAS No: 10458-14-7
产品详情
生物活性：
Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis.
体内研究：
Menthone (100 mg/kg, 关节注射, 14 天) 抑制 CIA 小鼠模型中 Th1 和 Th17 细胞的表达。Menthone (8-200 mg/kg, 灌胃, 每天一次, 5 周) 通过调节 Th2 偏向免疫平衡和减轻肥大细胞脱颗粒，来改善OVA 致敏和挑战的过敏性哮喘炎症小鼠模型中的肺部和气道的过敏性炎症状态。Menthone (100 mg/kg, 关节注射, 14 天) 有助于缓解 CIA 小鼠类风湿关节炎的局部炎症。Animal Model:OVA-sensitized and challenged allergic asthmatic inflammation mouse model
Dosage:8-200 mg/kg
Administration:i.g., daily, 5 weeks
Result: Reversed the allergic inflammation status through at medium and high doses.Decreased total cell number and eosinophilia into BALF.Increased the percentage of monocytes/macrophages and Th1 (IL-2+IFN-γ)/Th2 (IL-4+IL-5) cytokine secretion ratio in BALF.Decreased the levels of otaxin and protein in BALF and reduced the release of β-hexosaminidase from lung mast cells.Inhibited CC receptor 3 and CXC receptor 1 gene expression levels.
Animal Model:CIA mouse model
Dosage:100 mg/kg
Administration:Articulus injection, 14 days
Result:Decreased degree of posterior palm swelling and alleviated the inflammation in the local knuckles .Increased the levels of serum Creactive protein (CRP).Decreased the levels of ISGs (Ifit1, Isg15, and Mx1) and proinflammatory cytokines (TNF-α, IL-6, and IL-1β) in the finger joint tissues of the mice.Decreased the number of Th1 and Th17 cells.Decreased the levels of T-bet and RORγT gene transcription and increased the levels of GATA3 and Foxp3.Didn't produce severe hepatorenal toxicity.
体外研究：
Menthone (0.05-500 μM, 48 h) 对于小鼠原代肺肥大细胞活力的最佳浓度为 0.5、5 和 50 μM。Menthone (0.5-50 μM, 48 h) 抑制促炎细胞因子 TNF-α 的分泌，对LPS刺激的肺肥大细胞有抗炎作用。Menthone (100 μM, 24 h) 在 2fTGH 细胞中抑制 IFN-I 信号通路关键转录因子 STAT1 的激活，并促进 Tyk2 多泛素化，从而降低 Tyk2 蛋白水平。
Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis.
体内研究：
Menthone (100 mg/kg, 关节注射, 14 天) 抑制 CIA 小鼠模型中 Th1 和 Th17 细胞的表达。Menthone (8-200 mg/kg, 灌胃, 每天一次, 5 周) 通过调节 Th2 偏向免疫平衡和减轻肥大细胞脱颗粒，来改善OVA 致敏和挑战的过敏性哮喘炎症小鼠模型中的肺部和气道的过敏性炎症状态。Menthone (100 mg/kg, 关节注射, 14 天) 有助于缓解 CIA 小鼠类风湿关节炎的局部炎症。Animal Model:OVA-sensitized and challenged allergic asthmatic inflammation mouse model
Dosage:8-200 mg/kg
Administration:i.g., daily, 5 weeks
Result: Reversed the allergic inflammation status through at medium and high doses.Decreased total cell number and eosinophilia into BALF.Increased the percentage of monocytes/macrophages and Th1 (IL-2+IFN-γ)/Th2 (IL-4+IL-5) cytokine secretion ratio in BALF.Decreased the levels of otaxin and protein in BALF and reduced the release of β-hexosaminidase from lung mast cells.Inhibited CC receptor 3 and CXC receptor 1 gene expression levels.
Animal Model:CIA mouse model
Dosage:100 mg/kg
Administration:Articulus injection, 14 days
Result:Decreased degree of posterior palm swelling and alleviated the inflammation in the local knuckles .Increased the levels of serum Creactive protein (CRP).Decreased the levels of ISGs (Ifit1, Isg15, and Mx1) and proinflammatory cytokines (TNF-α, IL-6, and IL-1β) in the finger joint tissues of the mice.Decreased the number of Th1 and Th17 cells.Decreased the levels of T-bet and RORγT gene transcription and increased the levels of GATA3 and Foxp3.Didn't produce severe hepatorenal toxicity.
体外研究：
Menthone (0.05-500 μM, 48 h) 对于小鼠原代肺肥大细胞活力的最佳浓度为 0.5、5 和 50 μM。Menthone (0.5-50 μM, 48 h) 抑制促炎细胞因子 TNF-α 的分泌，对LPS刺激的肺肥大细胞有抗炎作用。Menthone (100 μM, 24 h) 在 2fTGH 细胞中抑制 IFN-I 信号通路关键转录因子 STAT1 的激活，并促进 Tyk2 多泛素化，从而降低 Tyk2 蛋白水平。
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