产品
编 号：F174014
分子式：C10H7N3S
分子量：201.25
分子式：C10H7N3S
分子量：201.25
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
100
In-stock
1g
120
In-stock
5g
360
In-stock
结构图
CAS No: 148-79-8
产品详情
生物活性：
Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling.
体内研究：
Thiabendazole (50 mg/kg, i.p., 27 天) 可减缓小鼠异种移植模型中的肿瘤生长。Thiabendazole (0/0.5/1/2/4/5/10/20 mg/L, Soak drug administration, 0-96 hpf) 通过细胞凋亡、氧化应激以及 PI3K/Akt 和 MAPK 通路的改变诱导斑马鱼发育缺陷。Animal Model:Wistar rats (adult male, 173±4 g average weight)
Dosage:90 mg/L, daily oral exposure for 90 days
Administration:p.o.
Result:Significantly changed the blood parameters in the sample.(1) Significantly altered blood parameters in the samples.(2) Red blood cells count and hemoglobin content were significantly reduced.(3) Platelet count dropped significantly.(4) The mean values of MCV (mean corpuscular volume) and MCH (mean corpuscular hemoglobin) were significantly increased.(5) Eosinophil content was significantly reduced.Significantly reduced the expression levels of immunoglobulins IgG and IgM.Significantly up-regulated the inflammatory factors (TNF-α, INF-γ, IL-1β, IL-6, L-10 and IL-13) in spleen tissue.and the cytokines CD4 increased and CD8 decreased.
Animal Model:Wild-type zebrafish (AB strain) and transgenic zebrafish models, including flk1:eGFP, olig2:dsRed, and L-fabp:dsRed;elastase:GFP)
Dosage:0/0.5/1/2/4/5/10/20 mg/L
Administration:Soak drug administration
Result:None of the embryos exposed to 20 and 50 mg/L of thiamendam survived. Induced apoptosis and cell cycle arrest in zebrafish larvae. Reduced the expression levels of antioxidant enzymes inducing ROS production and inflammatory response.Induced cardiovascular defects in zebrafish larvae.Caused motor neuron toxicity in zebrafish larvae.Caused hepatotoxicity and pancreatic toxicity.
体外研究：
Thiabendazole (0/50/100/200/300/400/500 μM, 24/48/72 h) 以时间和剂量依赖性方式抑制 B16F10 和 B16 细胞增殖。Thiabendazole (250 μM, 16 h) 抑制非洲爪蟾胚胎体内的血管生成，并破坏新建立的脉管系统。
Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling.
体内研究：
Thiabendazole (50 mg/kg, i.p., 27 天) 可减缓小鼠异种移植模型中的肿瘤生长。Thiabendazole (0/0.5/1/2/4/5/10/20 mg/L, Soak drug administration, 0-96 hpf) 通过细胞凋亡、氧化应激以及 PI3K/Akt 和 MAPK 通路的改变诱导斑马鱼发育缺陷。Animal Model:Wistar rats (adult male, 173±4 g average weight)
Dosage:90 mg/L, daily oral exposure for 90 days
Administration:p.o.
Result:Significantly changed the blood parameters in the sample.(1) Significantly altered blood parameters in the samples.(2) Red blood cells count and hemoglobin content were significantly reduced.(3) Platelet count dropped significantly.(4) The mean values of MCV (mean corpuscular volume) and MCH (mean corpuscular hemoglobin) were significantly increased.(5) Eosinophil content was significantly reduced.Significantly reduced the expression levels of immunoglobulins IgG and IgM.Significantly up-regulated the inflammatory factors (TNF-α, INF-γ, IL-1β, IL-6, L-10 and IL-13) in spleen tissue.and the cytokines CD4 increased and CD8 decreased.
Animal Model:Wild-type zebrafish (AB strain) and transgenic zebrafish models, including flk1:eGFP, olig2:dsRed, and L-fabp:dsRed;elastase:GFP)
Dosage:0/0.5/1/2/4/5/10/20 mg/L
Administration:Soak drug administration
Result:None of the embryos exposed to 20 and 50 mg/L of thiamendam survived. Induced apoptosis and cell cycle arrest in zebrafish larvae. Reduced the expression levels of antioxidant enzymes inducing ROS production and inflammatory response.Induced cardiovascular defects in zebrafish larvae.Caused motor neuron toxicity in zebrafish larvae.Caused hepatotoxicity and pancreatic toxicity.
体外研究：
Thiabendazole (0/50/100/200/300/400/500 μM, 24/48/72 h) 以时间和剂量依赖性方式抑制 B16F10 和 B16 细胞增殖。Thiabendazole (250 μM, 16 h) 抑制非洲爪蟾胚胎体内的血管生成，并破坏新建立的脉管系统。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备