产品
编 号：F173935
分子式：C18H24N2OS
分子量：316.46
分子式：C18H24N2OS
分子量：316.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 148741-30-4
产品详情
生物活性：
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.
体内研究：
Tyrphostin AG 879 (100 mg/kg；皮下注射；19 天内给药 10 次；持续 21 天；无胸腺、免疫抑制的 NOD/SCID 雌性小鼠) 处理在体内诱导移植的无胸腺 NOD/SCID 小鼠的癌症生长减少。Animal Model:Athymic, immunodepressed NOD/SCID female mice(20 g) with HTB-114 and HL-60 cells
Dosage:100 mg/kg
Administration:Subcutaneous injection; administered 10 times in 19 days; for 21 days
Result:Resulted in dramatic reductions in tumor sizes.
体外研究：
Tyrphostin AG 879 (0.5-50 μM；48 小时；HL-60、U-937、PC-3、HTB-82、HTB-114、TE-671、HTB-115 和 HTB-88 细胞) 处理显著且剂量依赖性降低所有细胞系的细胞增殖。 Tyrphostin AG 879 (0.5-50 μM；48 小时；HL-60、U-937、PC-3、HTB-82，HTB-114，TE-671，HTB-115 和 HTB-88 细胞) 处理也诱导剂量依赖性细胞凋亡增加，但 TE-671 和 HTB-88 细胞系除外。
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.
体内研究：
Tyrphostin AG 879 (100 mg/kg；皮下注射；19 天内给药 10 次；持续 21 天；无胸腺、免疫抑制的 NOD/SCID 雌性小鼠) 处理在体内诱导移植的无胸腺 NOD/SCID 小鼠的癌症生长减少。Animal Model:Athymic, immunodepressed NOD/SCID female mice(20 g) with HTB-114 and HL-60 cells
Dosage:100 mg/kg
Administration:Subcutaneous injection; administered 10 times in 19 days; for 21 days
Result:Resulted in dramatic reductions in tumor sizes.
体外研究：
Tyrphostin AG 879 (0.5-50 μM；48 小时；HL-60、U-937、PC-3、HTB-82、HTB-114、TE-671、HTB-115 和 HTB-88 细胞) 处理显著且剂量依赖性降低所有细胞系的细胞增殖。 Tyrphostin AG 879 (0.5-50 μM；48 小时；HL-60、U-937、PC-3、HTB-82，HTB-114，TE-671，HTB-115 和 HTB-88 细胞) 处理也诱导剂量依赖性细胞凋亡增加，但 TE-671 和 HTB-88 细胞系除外。
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