产品
编 号：F173648
分子式：C14H22ClNO
分子量：255.78
分子式：C14H22ClNO
分子量：255.78
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CAS No: 14860-49-2
产品详情
生物活性：
Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research.
体内研究：
Clobutinol (1-20 mg/kg; i.v. once) has no obvious effect on the airway of guinea-pigs.Clobutinol (1 and 10 mg/kg; i.v. once) affects heart rate and mean blood pressure of guinea pigs.Animal Model:Anaesthetized guinea-pigs
Dosage:1-20 mg/kg
Administration:Intravenous injection; 1-20 mg/kg once
Result:Showed no obvious effect on the airways, but affected the cardiovascular system considerably with a high dose.
Animal Model:Anesthetized closed-chest guinea pigs
Dosage:1 and 10 mg/kg
Administration:Intravenous injection; 1 and 10 mg/kg once
Result:Decreased the heart rate with a dose of 1 mg/kg, and decreased the heart rate and mean blood pressure with a dose of 10 mg/kg.
体外研究：
Clobutinol (10 μM) significantly inhibits the voltage-gated outward current in hERG-expressing cells.Clobutinol (0-1000 μM) inhibits the outward current in hERG transfected cells with an IC50 value of 1.9 μM.
Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research.
体内研究：
Clobutinol (1-20 mg/kg; i.v. once) has no obvious effect on the airway of guinea-pigs.Clobutinol (1 and 10 mg/kg; i.v. once) affects heart rate and mean blood pressure of guinea pigs.Animal Model:Anaesthetized guinea-pigs
Dosage:1-20 mg/kg
Administration:Intravenous injection; 1-20 mg/kg once
Result:Showed no obvious effect on the airways, but affected the cardiovascular system considerably with a high dose.
Animal Model:Anesthetized closed-chest guinea pigs
Dosage:1 and 10 mg/kg
Administration:Intravenous injection; 1 and 10 mg/kg once
Result:Decreased the heart rate with a dose of 1 mg/kg, and decreased the heart rate and mean blood pressure with a dose of 10 mg/kg.
体外研究：
Clobutinol (10 μM) significantly inhibits the voltage-gated outward current in hERG-expressing cells.Clobutinol (0-1000 μM) inhibits the outward current in hERG transfected cells with an IC50 value of 1.9 μM.
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