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编 号：F173615
分子式：C4H9NO5S
分子量：183.18
分子式：C4H9NO5S
分子量：183.18
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CAS No: 14857-77-3
产品详情
生物活性：
L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders.
体内研究：
L-Homocysteic acid (intraperitoneal injection, 4-11 mmol/kg) elicits seizures in rats during early postnatal development.L-Homocysteic acid (intraperitoneal injection, 100-1500 mg/kg) partially substitutes for NMDA, producing maximum values of 61-67% NMDA-lever responding at doses of 1000 and 560 mg/kg, respectively in Sprague-Dawley rats.Animal Model:Male albino rats of the Wistar strain
Dosage:4, 5.5, 8, 11 mM/kg
Administration:Intraperitoneal injection, daily for 14 days
Result:Induced flexion seizures at 4 mmol/kg.Led to intense tail flicking, pivoting, and locomotion.Decreased ECoG (electrocorticograms) activity for 5-9 min.
体外研究：
L-Homocysteic acid activates NMDA receptor with an EC50 value of 14 μM.L-Homocysteic acid (100 μM) induces large currents (1.8 nA) that is insensitive to the NMDA receptor-antagonist mixture in Purkinje cells.L-Homocysteic acid (250 μM, 30 min) potently induces an acute excitotoxic reaction in ex vivo chick embryo retina.L-Homocysteic acid (0-2 mM, 48 h) induces a concentration-dependent neurotoxic effect in rat primary neurons.
L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders.
体内研究：
L-Homocysteic acid (intraperitoneal injection, 4-11 mmol/kg) elicits seizures in rats during early postnatal development.L-Homocysteic acid (intraperitoneal injection, 100-1500 mg/kg) partially substitutes for NMDA, producing maximum values of 61-67% NMDA-lever responding at doses of 1000 and 560 mg/kg, respectively in Sprague-Dawley rats.Animal Model:Male albino rats of the Wistar strain
Dosage:4, 5.5, 8, 11 mM/kg
Administration:Intraperitoneal injection, daily for 14 days
Result:Induced flexion seizures at 4 mmol/kg.Led to intense tail flicking, pivoting, and locomotion.Decreased ECoG (electrocorticograms) activity for 5-9 min.
体外研究：
L-Homocysteic acid activates NMDA receptor with an EC50 value of 14 μM.L-Homocysteic acid (100 μM) induces large currents (1.8 nA) that is insensitive to the NMDA receptor-antagonist mixture in Purkinje cells.L-Homocysteic acid (250 μM, 30 min) potently induces an acute excitotoxic reaction in ex vivo chick embryo retina.L-Homocysteic acid (0-2 mM, 48 h) induces a concentration-dependent neurotoxic effect in rat primary neurons.
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