产品
编 号：F173547
分子式：C25H28N4O2
分子量：416.52
分子式：C25H28N4O2
分子量：416.52
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 148547-33-5
产品详情
生物活性：
GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases.
体内研究：
GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig.Animal Model:Male Dunkin Hartley guinea-pigs (350-450 g)
Dosage:0.3 mg/kg
Administration:Intraperitoneal injection
Result:Produced significant transient increases in extracellular 5-HT.
体外研究：
GR 125743 has a Kd of 0.61 nM for h5-HT1B.
GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases.
体内研究：
GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig.Animal Model:Male Dunkin Hartley guinea-pigs (350-450 g)
Dosage:0.3 mg/kg
Administration:Intraperitoneal injection
Result:Produced significant transient increases in extracellular 5-HT.
体外研究：
GR 125743 has a Kd of 0.61 nM for h5-HT1B.
产品资料
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