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编 号:F173279
分子式:C20H21N3O4
分子量:367.4
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生物活性:
Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.

体内研究:
Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion.

体外研究:
Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.
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