产品
编 号：F173047
分子式：C9H7NO
分子量：145.16
分子式：C9H7NO
分子量：145.16
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
120
In-stock
500mg
192
In-stock
1g
231
In-stock
5g
288
In-stock
结构图
CAS No: 148-24-3
产品详情
生物活性：
8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice.
体内研究：
8-Hydroxyquinoline (HOQ) (25-100 mg/kg，腹腔注射，单次给药) 导致 CD1 小鼠中微核多色红细胞(MPCE) 数量显着增加。 8-Hydroxyquinoline (8-HQ) (0.3%，皮肤给药，每周 4 次) 导致小鼠导致脱色毛发生长，生长模式随时间变化。Animal Model:CD1 mice
Dosage:25,50,100 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Resulted in a significant dose-related increase in the number of micronucleated polychromatic erythrocytes (MPCE) at the 24 h samplingtime for all doses tested.
Animal Model:C57BL mice
Dosage:0.3% 4 times weekly
Administration:Skin administration
Result:Caused depigmented hair to grow in patterns which change with time. Sufficiently frequent applications result in virtually complete depigmentation in young adult C57BL female mice, while single application causes isolated bands of depigmented hair.
体外研究：
8-Hydroxyquinoline (8HQ) (Compd 1) 在 MRC-5 细胞中显示细胞毒性，IC50 为 6.27 μM。8-Hydroxyquinoline (8-OHQ) (Compd 1) (与 CuCl2 混合，10.0 μM，1 小时) 与铜结合并形成复合物，可促进铜向人乳腺癌 DCIS 细胞的转运。8-Hydroxyquinoline (与 CuCl2 混合，,0-20.0 μM，1 或 8 小时) 与铜结合并形成复合物，在 DCIS 细胞中以时间和剂量依赖性方式诱导细胞死亡。 8-Hydroxyquinoline (与 CuCl2 混合，1-5 μM，2-12 小时) 抑制蛋白酶体糜蛋白酶样活性。8-Hydroxyquinoline (0-100 μM，30 分钟) 通过阻断 Raw 264.7 细胞中的 C/EBPb DNA 结合活性和 NF-κB 活化来抑制 NO 产生和 iNOS 表达，从而抑制炎症。
8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice.
体内研究：
8-Hydroxyquinoline (HOQ) (25-100 mg/kg，腹腔注射，单次给药) 导致 CD1 小鼠中微核多色红细胞(MPCE) 数量显着增加。 8-Hydroxyquinoline (8-HQ) (0.3%，皮肤给药，每周 4 次) 导致小鼠导致脱色毛发生长，生长模式随时间变化。Animal Model:CD1 mice
Dosage:25,50,100 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Resulted in a significant dose-related increase in the number of micronucleated polychromatic erythrocytes (MPCE) at the 24 h samplingtime for all doses tested.
Animal Model:C57BL mice
Dosage:0.3% 4 times weekly
Administration:Skin administration
Result:Caused depigmented hair to grow in patterns which change with time. Sufficiently frequent applications result in virtually complete depigmentation in young adult C57BL female mice, while single application causes isolated bands of depigmented hair.
体外研究：
8-Hydroxyquinoline (8HQ) (Compd 1) 在 MRC-5 细胞中显示细胞毒性，IC50 为 6.27 μM。8-Hydroxyquinoline (8-OHQ) (Compd 1) (与 CuCl2 混合，10.0 μM，1 小时) 与铜结合并形成复合物，可促进铜向人乳腺癌 DCIS 细胞的转运。8-Hydroxyquinoline (与 CuCl2 混合，,0-20.0 μM，1 或 8 小时) 与铜结合并形成复合物，在 DCIS 细胞中以时间和剂量依赖性方式诱导细胞死亡。 8-Hydroxyquinoline (与 CuCl2 混合，1-5 μM，2-12 小时) 抑制蛋白酶体糜蛋白酶样活性。8-Hydroxyquinoline (0-100 μM，30 分钟) 通过阻断 Raw 264.7 细胞中的 C/EBPb DNA 结合活性和 NF-κB 活化来抑制 NO 产生和 iNOS 表达，从而抑制炎症。
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