产品
编 号：F172638
分子式：C15H24N4O6S2
分子量：420.5
分子式：C15H24N4O6S2
分子量：420.5
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 148016-81-3
产品详情
生物活性：
Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria.
体内研究：
Doripenem (S 4661；MIC 范围为 2 至 16 μg/ml；皮下注射；1 小时和 4 小时输注；0.2 ml 注射) 显示出对铜绿假单胞菌的抗菌作用。 Doripenem (10、50、150 mg/kg；0.2 ml 体积；皮下注射 2 小时) 在 10 mg/kg 剂量对小鼠的 T1/2 为 0.41 小时，CL 为 673.9 mL/h?kg。 Pharmacokinetic Parameters of Doripenem in mice.SC (10 mg/kg) SC (50 mg/kg) SC (150 mg/kg)
Tmax (h)0.250.380.22
Cmax (μg/mL)16.359.7194.4
AUC0-24 (ng?h /mL)13.562.4168
t1/2 (h)0.410.340.44
CL (mL/h/kg)673.9783.3850.5
V (mL/kg)400.7384.7545.8
Animal Model:Specific-pathogen-free, female ICR mice weighing approximately 25 g with P. aeruginosa-infected thighs
Dosage:MIC range of 2 to 16 μg/ml
Administration:Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections
Result:Demonstrated antibacterial killing for P. aeruginosa.
Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria.
体内研究：
Doripenem (S 4661；MIC 范围为 2 至 16 μg/ml；皮下注射；1 小时和 4 小时输注；0.2 ml 注射) 显示出对铜绿假单胞菌的抗菌作用。 Doripenem (10、50、150 mg/kg；0.2 ml 体积；皮下注射 2 小时) 在 10 mg/kg 剂量对小鼠的 T1/2 为 0.41 小时，CL 为 673.9 mL/h?kg。 Pharmacokinetic Parameters of Doripenem in mice.SC (10 mg/kg) SC (50 mg/kg) SC (150 mg/kg)
Tmax (h)0.250.380.22
Cmax (μg/mL)16.359.7194.4
AUC0-24 (ng?h /mL)13.562.4168
t1/2 (h)0.410.340.44
CL (mL/h/kg)673.9783.3850.5
V (mL/kg)400.7384.7545.8
Animal Model:Specific-pathogen-free, female ICR mice weighing approximately 25 g with P. aeruginosa-infected thighs
Dosage:MIC range of 2 to 16 μg/ml
Administration:Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections
Result:Demonstrated antibacterial killing for P. aeruginosa.
产品资料
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