产品
编 号：F172204
分子式：C32H29F3N4O4S2
分子量：654.72
分子式：C32H29F3N4O4S2
分子量：654.72
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
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10mg
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25mg
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结构图
CAS No: 147776-06-5
产品详情
生物活性：
L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice.
体内研究：
L-161982 (5?mg/kg; i.p.; once per day for 2 weeks) reduces arthritis lesions and lesion progression in CIA mice.Animal Model:Female DBA/1 mice of 6 to 8?weeks old (collagen-induced arthritis (CIA) mice model)
Dosage:5?mg/kg
Administration:i.p.; once per day for 2 weeks
Result:Showed less joint swelling and lower arthritis score after 35?days post immunization.
体外研究：
L-161982 (10 μM; 2 hours) blocks PGE2-stimulated cell proliferation of HCA-7 cells.L-161982 (10 μM; 1 hour) blocks PGE2-stimulated ERK phosphorylation in HCA-7 cells.L-161982 induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells.
L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice.
体内研究：
L-161982 (5?mg/kg; i.p.; once per day for 2 weeks) reduces arthritis lesions and lesion progression in CIA mice.Animal Model:Female DBA/1 mice of 6 to 8?weeks old (collagen-induced arthritis (CIA) mice model)
Dosage:5?mg/kg
Administration:i.p.; once per day for 2 weeks
Result:Showed less joint swelling and lower arthritis score after 35?days post immunization.
体外研究：
L-161982 (10 μM; 2 hours) blocks PGE2-stimulated cell proliferation of HCA-7 cells.L-161982 (10 μM; 1 hour) blocks PGE2-stimulated ERK phosphorylation in HCA-7 cells.L-161982 induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells.
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