产品
编 号：F172169
分子式：C12H20Cl4N2O2
分子量：366.11
分子式：C12H20Cl4N2O2
分子量：366.11
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
779
In-stock
100mg
1090
In-stock
结构图
CAS No: 1477-57-2
产品详情
生物活性：
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes.
体内研究：
Win 18446 (200 mg/kg，口服 4、8 和 16 周) 显著降低睾丸内视黄酸浓度，严重损害精子发生，并导致不育。Animal Model:Six-month-old male New Zealand white rabbits.
Dosage:200 mg/kg.
Administration:Orally for 4, 8, and 16 weeks.
Result:Resulted in marked suppression of testicular weight over time.Dramatically suppressed spermatogenesis.Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility.
体外研究：
WIN 18446 (1 μM，24 小时) 能够抑制包含生殖细胞和体细胞的全睾丸培养物中的 Stra8 表达。
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes.
体内研究：
Win 18446 (200 mg/kg，口服 4、8 和 16 周) 显著降低睾丸内视黄酸浓度，严重损害精子发生，并导致不育。Animal Model:Six-month-old male New Zealand white rabbits.
Dosage:200 mg/kg.
Administration:Orally for 4, 8, and 16 weeks.
Result:Resulted in marked suppression of testicular weight over time.Dramatically suppressed spermatogenesis.Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility.
体外研究：
WIN 18446 (1 μM，24 小时) 能够抑制包含生殖细胞和体细胞的全睾丸培养物中的 Stra8 表达。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备