产品
编 号：F171945
分子式：C31H35N2NaO11
分子量：634.61
分子式：C31H35N2NaO11
分子量：634.61
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
720
In-stock
500mg
询价
询价
结构图
CAS No: 1476-53-5
产品详情
生物活性：
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity.
体内研究：
Novobiocin sodium (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.Animal Model:30 g adult female Swiss mice (sepsis induced by the penicillin-susceptible strain (AR33118))
Dosage:25, 50, 100, 200 mg/kg
Administration:S.c.; given at 1, 5, 24 and 48 h after infection
Result:Showed anti-infection activity in mice infected with amoxicillin-resistant S. pneumoniae.
体外研究：
Novobiocin sodium (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90.Novobiocin sodium (200 μM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.Novobiocin sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2.
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity.
体内研究：
Novobiocin sodium (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.Animal Model:30 g adult female Swiss mice (sepsis induced by the penicillin-susceptible strain (AR33118))
Dosage:25, 50, 100, 200 mg/kg
Administration:S.c.; given at 1, 5, 24 and 48 h after infection
Result:Showed anti-infection activity in mice infected with amoxicillin-resistant S. pneumoniae.
体外研究：
Novobiocin sodium (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90.Novobiocin sodium (200 μM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.Novobiocin sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2.
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