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编 号：F171784
分子式：C21H24N2O4
分子量：368.43
分子式：C21H24N2O4
分子量：368.43
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CAS No: 147568-66-9
产品详情
生物活性：
Carmoterol is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC50 of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol can be used for the research of asthma and chronic obstructive pulmonary disease (COPD).
体内研究：
Bronchoconstriction is induced in normal guinea-pigs by intravenous administration of graded doses of Acetylcholine (10, 20 and 40 mg/kg) and Histamine (5, 10 and 20 mg/kg) or in actively sensitized animals by Ovalbumin (5 mg/kg). Carmoterol (from 0.3 to 100 pmol) is given by superfusion onto the tracheal mucosa for 5 min before challenge. Carmoterol causes a dose-dependent inhibition of the acetylcholine-induced bronchoconstriction with the ED50 of 16.7 pmol.Animal Model:Male Dunkin Hartley guinea-pigs (weighing 360-380 g)
Dosage:0.3 to 100 pmol.
Administration:Given by superfusion (0.01 mL/min) onto the tracheal mucosa for 5 min before challenge.
Result:Caused a dose-dependent inhibition of the Acetylcholine-induced bronchoconstriction. Was very potent against Histamine and Ovalbumin-induced reaction, being effective already at 1 pmol.
Carmoterol is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC50 of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol can be used for the research of asthma and chronic obstructive pulmonary disease (COPD).
体内研究：
Bronchoconstriction is induced in normal guinea-pigs by intravenous administration of graded doses of Acetylcholine (10, 20 and 40 mg/kg) and Histamine (5, 10 and 20 mg/kg) or in actively sensitized animals by Ovalbumin (5 mg/kg). Carmoterol (from 0.3 to 100 pmol) is given by superfusion onto the tracheal mucosa for 5 min before challenge. Carmoterol causes a dose-dependent inhibition of the acetylcholine-induced bronchoconstriction with the ED50 of 16.7 pmol.Animal Model:Male Dunkin Hartley guinea-pigs (weighing 360-380 g)
Dosage:0.3 to 100 pmol.
Administration:Given by superfusion (0.01 mL/min) onto the tracheal mucosa for 5 min before challenge.
Result:Caused a dose-dependent inhibition of the Acetylcholine-induced bronchoconstriction. Was very potent against Histamine and Ovalbumin-induced reaction, being effective already at 1 pmol.
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