产品
编 号：F171556
分子式：C9H15ClN2O
分子量：202.68
分子式：C9H15ClN2O
分子量：202.68
产品类型
规格
价格
是否有货
1mg
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 147388-83-8
产品详情
生物活性：
ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease.
体内研究：
ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze.Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment.ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD.ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression.Animal Model:Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model
Dosage:0.6 mg/kg
Administration:Intraperitoneal injection; once daily; for two weeks
Result:Effectively improved spatial memory.
ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease.
体内研究：
ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze.Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment.ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD.ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression.Animal Model:Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model
Dosage:0.6 mg/kg
Administration:Intraperitoneal injection; once daily; for two weeks
Result:Effectively improved spatial memory.
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