产品
编 号：F170831
分子式：C13H11NO5
分子量：261.23
分子式：C13H11NO5
分子量：261.23
产品类型
规格
价格
是否有货
500mg
320
In-stock
1g
400
In-stock
结构图
CAS No: 14698-29-4
产品详情
生物活性：
Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice.
体内研究：
Oxolinic acid (32 mg/kg; i.p.) induces hyperactivity in mice.Animal Model:Male Swiss albino CD1 mice (22-25 g)
Dosage:16 mg/kg, 32 mg/kg, 64 mg/kg, 128 mg/kg
Administration:Intraperitoneal injection
Result:Stimulated the horizontal activity of mice, culminated at the 32 mg/kg dose but disappeared at the highest tested dose, 128 mg/kg.
体外研究：
Oxolinic acid (2-5 ug/mL) inhibits 115 strains of E. coli.Oxolinic acid (0-31 ug/mL) inhibits 94 % of the 44 strains of Proteus mirabilis .Oxolinic acid (>5 ug/mL) inhibits all strains of Strept. Faecalis.Oxolinic acid (>2 ug/mL) causes chromosomal DNA supercoiling to decrease in the two wild-type E. coli K-12 strains tested, DM4100 and NI747.Oxolinic acid reduces chromosomal DNA supercoiling and inhibits RNA synthesis in E. coli.
Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice.
体内研究：
Oxolinic acid (32 mg/kg; i.p.) induces hyperactivity in mice.Animal Model:Male Swiss albino CD1 mice (22-25 g)
Dosage:16 mg/kg, 32 mg/kg, 64 mg/kg, 128 mg/kg
Administration:Intraperitoneal injection
Result:Stimulated the horizontal activity of mice, culminated at the 32 mg/kg dose but disappeared at the highest tested dose, 128 mg/kg.
体外研究：
Oxolinic acid (2-5 ug/mL) inhibits 115 strains of E. coli.Oxolinic acid (0-31 ug/mL) inhibits 94 % of the 44 strains of Proteus mirabilis .Oxolinic acid (>5 ug/mL) inhibits all strains of Strept. Faecalis.Oxolinic acid (>2 ug/mL) causes chromosomal DNA supercoiling to decrease in the two wild-type E. coli K-12 strains tested, DM4100 and NI747.Oxolinic acid reduces chromosomal DNA supercoiling and inhibits RNA synthesis in E. coli.
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