产品
编 号：F019272
分子式：C10H12O
分子量：148.2
分子式：C10H12O
分子量：148.2
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
280
In-stock
500mg
320
In-stock
结构图
CAS No: 104-46-1
产品详情
生物活性：
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer.
体内研究：
Anethole (62.5-500 mg/kg; 腹腔注射，单剂量) 在 LPS (1.5 mg/kg) (HY-D1056) 诱导的 BALB/C 小鼠中具有抗炎作用。Anethole (250-1000 mg/kg; 口服; 隔天一次，连续 60 天) 在埃尔利希腹水瘤瑞士白化小鼠中具有抗肿瘤作用。Animal Model:BALB/C mice model induced by LPS
Dosage:62.5 mg/kg, 125 mg/kg, 250 mg/kg, 500 mg/kg
Administration:Intraperitoneal injection (i.p.), single dose. After LPS treatment (1.5 mg/kg; intratracheal injection, single dose).
Result:Decreased total protein concentration. Decreased numbers of inflammatory cells including neutrophils and macrophages. Decreased the inflammatory mediators MMP-9, TNF-α, NO. Decreased LPS-induced histopathological changes. Suppressed the activation of NF-κB by blocking IκB-α degradation.
Animal Model:Ehrlich ascites tumour (ETC) Swiss albino mouse model
Dosage:250 mg/kg; 500 mg/kg; 1000 mg/kg
Administration:Oral gavage (p.o.); Once every other day for 60 consecutive days. After implantation of ETC cells (2.5×106 cells/mouse) into the right hind paw muscle of mice.
Result:Reduced tumor weight and volume in mice.Prolonged the survival time of ETC mice.
体外研究：
Anethole (0.5-1 μM; 1 h) 能抑制 H2O2 (300 μM) 诱导的人皮肤成纤维细胞 CRL1474 的细胞凋亡和活力下降。Anethole 对植物化学物质 (包括多果香和 2E-十一烯醛) 对酿酒酵母和白色念珠菌的抗真菌活性具有协同作用。
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer.
体内研究：
Anethole (62.5-500 mg/kg; 腹腔注射，单剂量) 在 LPS (1.5 mg/kg) (HY-D1056) 诱导的 BALB/C 小鼠中具有抗炎作用。Anethole (250-1000 mg/kg; 口服; 隔天一次，连续 60 天) 在埃尔利希腹水瘤瑞士白化小鼠中具有抗肿瘤作用。Animal Model:BALB/C mice model induced by LPS
Dosage:62.5 mg/kg, 125 mg/kg, 250 mg/kg, 500 mg/kg
Administration:Intraperitoneal injection (i.p.), single dose. After LPS treatment (1.5 mg/kg; intratracheal injection, single dose).
Result:Decreased total protein concentration. Decreased numbers of inflammatory cells including neutrophils and macrophages. Decreased the inflammatory mediators MMP-9, TNF-α, NO. Decreased LPS-induced histopathological changes. Suppressed the activation of NF-κB by blocking IκB-α degradation.
Animal Model:Ehrlich ascites tumour (ETC) Swiss albino mouse model
Dosage:250 mg/kg; 500 mg/kg; 1000 mg/kg
Administration:Oral gavage (p.o.); Once every other day for 60 consecutive days. After implantation of ETC cells (2.5×106 cells/mouse) into the right hind paw muscle of mice.
Result:Reduced tumor weight and volume in mice.Prolonged the survival time of ETC mice.
体外研究：
Anethole (0.5-1 μM; 1 h) 能抑制 H2O2 (300 μM) 诱导的人皮肤成纤维细胞 CRL1474 的细胞凋亡和活力下降。Anethole 对植物化学物质 (包括多果香和 2E-十一烯醛) 对酿酒酵母和白色念珠菌的抗真菌活性具有协同作用。
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